Quality of life of HIV positive people

Olga Shivairová, Viktor Aster, Jaroslav Kőnig, Ladislav Machala, Richard Braun, Marie Staňková


The study aims to investigate factors that infuence the quality of life of HIV infected people. Based on findigns from a number of researches high level of CD4+ lymphocytes count, low viral load, employment and social support have been found to have a positive effect on the quality of life of HIV infected individuals, while depression, low CD4+ lymphocytes count, high level of viraemia, and comorbidities (such as pneumocystis pneumonia, hepatitis C, cytomegalovirus infection) have a negative effect on the quality of life. The role of gender in the quality of life of HIV infected people is as yet not clear. Some researches document lower quality of life in HIV positive women compared to HIV positive men, while others don’t show any difference. Antiretroviral therapy has both positive and negative effect on quality of life. There is an indication that co-infection with hepatitis G virus may positively influence health related aspects of the quality of life of HIV infected people. In a further research, the authors will examine the effects of HGV infection on general quality of life in HIV positive individuals. As yet very little research has been done in this area. It is hoped that by discovering the range of factors that may influence the quality of life of HIV infected people, their needs will be better understood, which may in turn increase their adherence to antiretroviral therapy and lower their tendency towards risky behavior.

(Fulltext in Czech)


quality of life, HIV, AIDS, antiretroviral therapy


ASTER, V., et al. (2008). GBV-C/HIV coinfected patients from AIDS Center Prague have higher CD4 cell counts and probably better quality of life. Ninth Internationl Congress on Drug Therapy in HIV Infection, P 295, s. 113.

BAUMEISTER, R. F.(1991). Meanings of Life. New York: The Guilford Press.

BING, E. G, et al. (2000). Health-related quality of life among people with HIV disease : Results from the Multicenter AIDS Cohort Study. Quality of Life Research, 9, 55–63.

BINQUET, C., et al. (2000). Prognostic factors of survival of HIV-infected patients with Cytomegalovirus disease: Aquitaine Cohort, 1986–1997. European Journal of Epidemiology, 16, 425–432.

BLALOCK, A. C., & McDANIEL, J.S., FARBER, E.W. (2002). Effect of Employment on Quality of Life and Psychological Functioning in Patients With HIV/AIDS. Psychosomatics, 43, 4, 400–404. Dostupné též na WWW: <http://psy.psychiatryonline.org/…ull/43/5/400>.

CALL, S. A, et al. (2000). Health-related quality of life and virologic outcomes in an HIV clinic. Quality of Life Research, 9, 977–985.

CEDERFJAELL, C., et al. (2001). Gender Differences in Perceived Health-Related Quality of Life Among Patients with HIV Infection. AIDS Patient Care and STDs, 15, 1, 31–39.

COOK, J. A., et al. (2002). Effects of Depressive Symptoms and Mental Health Quality of Life on Use of Highly Active Antiretroviral Therapy Among HIV-Seropositive Women. Journal of Acquired Immune Deficiency Syndromes, 30, 4, 401–409. Dostupné též na WWW:<http://journals.lww.com/…ealth.5.aspx>.

DOUAIHY, A., & SINGH, N. (2001). Factors Affecting Quality of Life in Patients With HIV Infection. The AIDS Reader, 11, 9, 450–461.

DRAGOMIRECKÁ, E., et al. (2006). SQUALA. Praha: Psychiatrické centrum Praha.

DRAY-SPIRA, R., et al. (2007). Living and working with HIV in France in 2003 : results from the ANRS-EN12-VESPA Study. AIDS, 21, 1, 29–36. Dostupné též na WWW: <http://journals.lww.com/…2003_.5.aspx>.

ELLER, S. L. (2001). Quality of Life in Persons Living With HIV. Clinical Nursing Research, 10, 4, 401–423.

FLANNELLY, L. T., & INOUYE, J. (2001). Relationships of religion, health status, and socioeconomic status to the quality of life of individuals who are HIV positive. Issues in Mental Health Nursing, 22, 253–272.

FOGARTY, A., et al. (2007). Factors distinguishing employed from unemployed people in Positive Health Study. AIDS, 21, 1, 37–42.

GILL, Ch, et al. (2002). Relationship of HIV Viral Loads, CD4 Counts, and HAART Use to Health-Related Quality of Life. Journal of Acquired Immune Deficiency Syndromes, 30, 5, 485–492. Dostupné též na WWW: <http://journals.lww.com/…,_and.4.aspx>.

GROSSMAN, H. A, et al. (203). Quality of Life and HIV : Current Assessment Tools and Future Directions for Clinical Practice. The AIDS Reader, 13, 12, 583–597.

GULLONE, E., & CUMMINS, R.A. (2002). The Universality of Subjective Wellbeing Indicators. Dordrecht : Kluwer Academic Publishers.

HECKMAN, T. G. (2003). The chronic illness quality of life (CIQOL) model: explaining life satisfaction in people living with HIV disease. Health Psychology, 22, 2, 140–147.

HUANGUANG, J., et al. (2005). Predictors of Changes in Health-Related Quality of Life Among Men with HIV Infection in the HAART Era. AIDS Patient Care and STDs,19, 6, 395–405.

HUGHES, J., et al. (2004). The health-related quality of life of people living with HIV/AIDS. Disability and Rehabilitation, 26, 6, 371–376.

CHANDRA, P. S., et al. (2003). Relationship of psychological morbidity and quality of life to illness-related disclosure among HIV-infected persons. Journal of Psychosomatic Research, 54, 3, 199–203.

JOMBÍKOVÁ, E., & KOVÁČ, D. (2007). Optimism and quality of life in adolescents – Bratislava secondary school students. Studia psychologica,49, 4, 347–356.

KALICHMAN, S. C., et al. (2005). Depression and Thoughts of Suicide Among Middle-Aged and Older Persons Living With HIV-AIDS. Psychiatric Services, 51, 7, 903–907. Dostupné též na WWW:< http://www.ps.psychiatryonline.org/…full/51/7/90>.

KEBZA, V., & ŠOLCOVÁ, I. (2008). Hlavní koncepce psychické odolnosti. Československá psychologie, 52, 1–19.

KEMPPAINEN, J. K. (2001). Predictors of quality of life in AIDS patients. Journal of the Association of Nurses in AIDS Care,12, 1, 61–70.

KIPPAX, S., et al. (2007). Living with HIV. Recent research from France and the French Caribbean (VESPA study), Australia, Canada and the United Kingdom. AIDS, 21, 1, 1–4. Dostupné též na WWW: <http://journals.lww.com/…e_and.1.aspx>

LOW-BEER, S., et al. (2000). Health related quality of life among persons with HIV after use of protease inhibitors. Quality of Life Research, 9, 941–949.

MARTIN, D. J. (2007). Working with HIV. American Psychological Association. MICHALOS, A. C., et al. (2000). Health and the Quality of Life. Social Indicators Research, 51, 245–286.

MINERS, A. H., et al. (2001). Health-Related Quality of Life in Individuals Infected with HIV in the Era of HAART. HIV Clinical Trials, 6, 2, 484–492.

MRUS, J. M., et al. (2005). Gender differences in health-related quality of life in patients with HIV/AIDS. Quality of Life Research,14, 1, 479–491.

MURRI, R., et al. (2003). Determinants of health – related quality of life in HIV-infected patients. AIDS Care, 15, 4, 581–590.

Národní referenční laboratoř pro AIDS. (2007). Stav HIV infekce v ČR. Praha: Státní zdravotní ústav.

NIEUWKERK, P. T., et al. (2001). Long-term quality of life outcomes in three antiretroviral treatment strategies for HIV-1 infection. AIDS, 15, 15, 1985–1991.

PENEDO, F. J., et al. (2003). Personality, quality of life and HAART adherence among men and women living with HIV/AIDS. Journal of Psychosomatic Research, 54, 3, 271–278.

POTRIBNÁ, J., & DRAGOMIRECKÁ, E.(2001). Quality of life of HIV/AIDS patients in comparison with a control group. Homeostasis, 41, 5, 176–181.

POTRIBNÁ, J. (2002). Psychiatrické aspekty nemoci HIV/AIDS. Možnosti ovlivnění kvality života HIV infikovaných osob. Ostrava. Nepublikovaná dizertační práce.

PRÉAU, M., et al. (2007). Health-related quality of life in French people living with HIV in 2003: results from the ANRS-EN12-VESPA Study. AIDS, 21, 1, 19–28. Dostupné též na WWW: <http://journals.lww.com/…eople.4.aspx>

SHERBOURNE, C. D., et al. (2000). Impact of Psychiatric Conditions on Health-Related Quality of Life in Persons With HIV Infection. American Journal of Psychiatry,157, 2, 248–254. Dostupné též na WW:< http://ajp.psychiatryonline.org/…ll/157/2/248>.

SCHONNESSON, L. N. (2002). Psychological and existential issues and quality of life in people living with HIV infection. AIDS Care, 14, 3, 399–404.

TATE, D., et al.(2003). The Impact of Apathy and Depression on Quality of Life in Patients Infected with HIV. AIDS Patient Care and STDs, 17, 3, 115–120.

TILLMANN, H. L., et al. (2006). Differential influence of different hepatitis viruses on quality of life in HIV positive patients. European journal of medical research, 29;11(9), 381–385. Dostupné též na WWW: <http://daignet.de/…Tillmann.pdf>.

TILLMANN H. L., et al. (2004). GB virus C infection and quality of life in HIV-positive patients. AIDS Care, 16(6), 736–43.

TUCK, I, et al. (2001). Spirituality and psychosocial factors in persons living with HIV. Journal of Advance Nursing, 33, 6, 776–783.

VAN DE VELDE, I. (2004). Positive answers. Brussels : Sensoa.

WEINFURT, K., et al. (2000). Relationship Between CD4 Count, Viral Burden, and Quality of Life Over Time in HIV-1-Infected Patients. Medical Care, 38, 4, 404–410.

XIANG, J., WUNSCHMANN, S., DIEKEMA, D. J., et al. (2001). Effect coinfection with GB Virus C on survival among patients with HIV infection. New England Journal of Medicine, 345(10), 707–714. Dostupné též na WWW: <http://content.nejm.org/…l/345/10/707>.

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